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Advantages of the polysaccharides from Gracilaria lemaneiformis over metformin in antidiabetic effects on streptozotocin-induced diabetic mice

Wen, Lingrong, Zhang, Yunlin, Sun-Waterhouse, Dongxiao, You, Lijun, Fu, Xiong
RSC advances 2017 v.7 no.15 pp. 9141-9151
Gracilaria, animal disease models, antioxidants, blood, citric acid, diabetes, dietary supplements, dose response, enzyme activity, functional foods, galactose, glucokinase, glucose, glycemic effect, insulin, islets of Langerhans, lipid metabolism, lipid peroxidation, liver, malondialdehyde, metformin, mice, molecular weight, oxidative stress, polysaccharides, renal function, streptozotocin, superoxide dismutase, urea nitrogen
In the present study, polysaccharides from Gracilaria lemaneiformis (GLP) were obtained by citric acid extraction, and had a low molecular weight (21.2 kDa) with a high amount of galactose. GLP showed effective inhibitory effects on α-amylase activity. After a six-week animal trial, GLP was found to combat streptozotocin (STZ)-induced diabetes and associated with oxidative stress, via its regulation of glucose and lipid metabolism, repair of pancreatic β-cells, protection of liver and kidney function, promotion of the activities of endogenous antioxidant enzymes, and suppression of lipid peroxidation. A dose-dependent manner was found in these examinations except for the glucokinase level, superoxide dismutase activity, and malondialdehyde content. GLP treatments were also more effective at regulating the insulin level, lipidemic parameters and blood urea nitrogen level than metformin treatment. Thus, GLP is more advantageous than metformin not only in the naturalness of GLP but also in the action of combating STZ-induced diabetes. Accordingly, GLP may be utilized as a potential functional food supplement for diabetes prevention in the future.