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Acylphloroglucinol and tocotrienol derivatives from the fruits of Garcinia multiflora

Author:
Liu, Hui, Gan, Fei, Jin, Shan, Li, Jun, Chen, Yu, Yang, Guangzhong
Source:
RSC advances 2017 v.7 no.47 pp. 29295-29301
ISSN:
2046-2069
Subject:
Garcinia, cytotoxicity, fruits, human cell lines, humans, inhibitory concentration 50, mass spectrometry, neoplasm cells, neoplasms, nuclear magnetic resonance spectroscopy, tocotrienols
Abstract:
A new regioisomeric pair of garcimultine A (1) and B (2), one new tocotrienol derivative garcimultine C (8), together with six known compounds were isolated from the fruits of Garcinia multiflora. Their structures were determined by extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. The regioisomeric garcimultine A (1) and B (2) were not separated due to the rapid equilibration between the two isomeric forms. The compounds isolated were evaluated for their cytotoxicity against four cancer cell lines (HepG2, A549, SGC7901, MCF-7). All isolated compounds showed moderate cytotoxicity on four human tumor cell lines with IC₅₀ values ranging from 4.06 to 35.61 μM.
Agid:
6361618