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Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii
- Gao, Yu-Hong, Zheng, Rui, Li, Jing, Kong, Wei-Song, Liu, Xin, Ye, Lin, Mi, Qi-Li, Kong, Wei-Song, Zhou, Min, Yang, Guang-Yu, Hu, Qiu-Fen, Du, Gang, Yang, Hai-Ying, Li, Xue-Mei
- Journal of Asian natural products research 2019 v.21 no.4 pp. 316-322
- Diaporthe, Staphylococcus aureus, diphenyl ethers, endophytes, fermented foods, fungi, nuclear magnetic resonance spectroscopy
- Three new diphenyl ethers (1-3), together with four known isopentylated diphenyl ethers derivatives (4-7), were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed strong inhibitions with inhibition zone diameters (IZD) of 20.2 ± 2.5 mm and 17.9 ± 2.2 mm, respectively. Compound 3 also showed good inhibition with IZD 15.2 ± 1.8 mm. The IZD data of compound 1 is close to that of positive control with IZD 21.9 ± 2.1 mm.