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A new phenanthrene dimer from Dendrobium palpebrae

Author:
Kyokong, Napat, Muangnoi, Chawanphat, Thaweesest, Wuttinont, Kongkatitham, Virunh, Likhitwitayawuid, Kittisak, Rojsitthisak, Pornchai, Sritularak, Boonchoo
Source:
Journal of Asian natural products research 2019 v.21 no.4 pp. 391-397
ISSN:
1477-2213
Subject:
Dendrobium, antioxidant activity, dose response, hydroxyl radicals, phenanthrenes, superoxide dismutase
Abstract:
A new phenanthrene dimer, namely dendropalpebrone (1), was isolated from the whole plant of Dendrobium palpebre, along with nine known compounds (2–10). All of the isolates were evaluated for their hydroxyl radical scavenging effects using a deoxyribose assay. Dendroflorin (10) showed an appreciable activity, and therefore was selected for further studied in RAW264.7 cells. Compound 10 significantly decreased ROS in H₂O₂-stimulated RAW264.7 cells in a dose-dependent manner, and improved activity of SOD, GPx, and CAT enzymes.
Agid:
6361828