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Intestinal permeability of mitragynine in rats using in situ absorption model

Author:
Jagabalan, J. D. Yuvenesan, Murugaiyah, Vikneswaran, Zainal, Hadzliana, Mansor, Sharif Mahsufi, Ramanathan, Surash
Source:
Journal of Asian natural products research 2019 v.21 no.4 pp. 351-363
ISSN:
1477-2213
Subject:
P-glycoproteins, absorption, azithromycin, ciprofloxacin, drugs, models, permeability, propranolol, rats, small intestine
Abstract:
The intestinal permeability of mitragynine was investigated in situ using a single pass intestinal perfusion (SPIP) absorption model, in small intestine of rat using mitragynine in the absence/presence of the permeability markers, P-gp and/or CYP3A4 inhibitors. Mitragynine demonstrated high intestinal permeability (Pₑff of 1.11 × 10⁻⁴ cm/s) that is in the range of highly permeable drugs such as propranolol (Pₑff of 1.27 × 10⁻⁴ cm/s) indicating that it readily crosses the intestine. The addition of azithromycin (P-glycoprotein inhibitor) and ciprofloxacin (CYP3A4 inhibitor) or combination of both has no effect on intestinal permeability of mitragynine across the rat small intestine.
Agid:
6361831