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Bioactive sesquiterpenoids and steroids from the resinous exudates of Commiphora myrrha

Author:
Ge, Chi-Yu, Zhang, Jun-Li
Source:
Natural product research 2019 v.33 no.3 pp. 309-315
ISSN:
1478-6427
Subject:
Commiphora myrrha, carcinoma, cell movement, dose response, enantiomers, human cell lines, humans, liver, sesquiterpenoids, spectral analysis, steroids
Abstract:
Chemical investigation of the resinous exudates of Commiphora myrrha has led to the isolation of four sesquiterpenes (1a/1b, 2, and 3), including one pair of new sesquiterpene enantiomers (1a/1b), one new racemic mixture 2, and two steroids (4 and 5). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1a/1b were determined by CD analysis. The antimigratory potential of compounds 1–5 were evaluated and compound 3 was found to inhibit human hepatocellular liver carcinoma HepG2 cell migration in dose-dependent manner.
Agid:
6361835