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Two new polyketides from the fungus Penicillium oxalicum MHZ153

Author:
Ren, Yi, Chao, Ling-Hui, Sun, Jing, Chen, Xiao-Nan, Yao, Hui-Na, Zhu, Zhi-Xiang, Dong, Dan, Liu, Ting, Tu, Peng-Fei, Li, Jun
Source:
Natural product research 2019 v.33 no.3 pp. 347-353
ISSN:
1478-6427
Subject:
Penicillium oxalicum, ethyl acetate, fungi, inhibitory concentration 50, neuroglia, nitric oxide, polyketides, solid state fermentation, spectral analysis, spectroscopy
Abstract:
Two new polyketides, penicilloxalones A (1) and B (2), together with 13 known compounds (3–15), were isolated from the ethyl acetate extract of the solid substrate fermentation cultures of the fungus Penicillium oxalicum MHZ153. The structures of the isolates were determined by spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 7 and 11 showed inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC₅₀ values of 0.9 ± 0.2 μM and 87.9 ± 0.7 μM, respectively.
Agid:
6361842