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A new β-tetralonyl glucoside from the Santalum album derived endophytic fungus Colletotrichum sp. GDMU-1

Author:
Liu, Weiyang, Chen, Senhua, Li, Jing, Yang, Xuemei, Yan, Chong, Liu, Hongju
Source:
Natural product research 2019 v.33 no.3 pp. 354-359
ISSN:
1478-6427
Subject:
Colletotrichum, Santalum album, anti-inflammatory activity, chemical structure, endophytes, fungi, glucosides, inhibitory concentration 50, leaves, lipopolysaccharides, nitric oxide, spectral analysis
Abstract:
A new β-tetralonyl glucoside, methylberchemiaside (1), along with five known compounds (2–6) were isolated from a fungus Colletotrichum sp. GDMU-1 derived from the leaves of Santalum album. Their structures were determined by detailed analysis of spectroscopic data. All compounds were tested for the inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-treated RAW264.7 cells. Among them, compounds 4 and 5 showed moderate anti-inflammatory activity with IC₅₀ value of 30.4 and 8.9 μM, respectively.
Agid:
6361843