PubAg

Main content area

Directed C3-Alkoxymethylation of Indole via Three-Component Cascade Reaction

Author:
Pi, Chao, Yin, Xiaohang, Cui, Xiuling, Ma, Yuwen, Wu, Yangjie
Source:
Organic letters 2019 v.21 no.7 pp. 2081-2084
ISSN:
1523-7052
Subject:
aldehydes, chemical reactions, chemical structure, indoles, regioselectivity
Abstract:
An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a variety of C3-alkoxymethylaed free (N–H) indole in up to 98% yield with excellent regioselectivity. The titled products are useful building blocks in organic synthesis.
Agid:
6363053