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Diastereoselective Intramolecular Hydride Transfer under Brønsted Acid Catalysis

Author:
Wang, Bin, Gandamana, Dhika Aditya, Gagosz, Fabien, Chiba, Shunsuke
Source:
Organic letters 2019 v.21 no.7 pp. 2298-2301
ISSN:
1523-7052
Subject:
Bronsted acids, alcohols, alkenes, catalytic activity, chemical reactions, chemical structure, diastereoselectivity, hydrides, methyl ethers
Abstract:
A diastereoselective hydride transfer process has been developed under Brønsted acid-catalyzed reaction conditions using methyl ethers or acetals as hydride donors and tertiary alcohols or alkenes as precursors of carbocation. The method enables construction of complex molecules having multiple stereogenic centers from rather simple and readily available starting materials with predictable diastereoselective control.
Agid:
6363099