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DNA tetrahedron-based nanogels for siRNA delivery and gene silencing
- Xue, Han, Ding, Fei, Zhang, Jiao, Guo, Yuanyuan, Gao, Xihui, Feng, Jing, Zhu, Xinyuan, Zhang, Chuan
- Chemical communications 2019 v.55 no.29 pp. 4222-4225
- DNA, chemical compounds, chemical reactions, gene expression, gene silencing, geometry, nanoparticles, small interfering RNA
- DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. With a compact architecture that embeds functional siRNA inside, the self-assembled nanogel can efficiently enter cells and knock down the target gene expression, making them potential noncationic vectors for functional nucleic acid delivery.