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Gold(i)-catalyzed enantioselective synthesis of polycyclic indoline skeletons and enantiomerically enriched β-substituted tryptamine-allenes by kinetic resolution

Author:
Zhang, Yan-Yan, Wei, Yin, Shi, Min
Source:
Chemical communications 2019 v.55 no.29 pp. 4210-4213
ISSN:
1364-548X
Subject:
chemical reactions, enantioselective synthesis, gold, moieties, tryptamine
Abstract:
A gold(i)-catalyzed highly efficient kinetic resolution of indole–allene derivatives has been demonstrated, providing enantiomerically enriched polycyclic indolines possessing four stereogenic centers including an all-carbon quaternary center in a spirocyclic framework and β-substituted tryptamine derivatives in good to excellent ee values and high s selectivities with good functional group tolerance under mild conditions in an atom-economical way.
Agid:
6363356