Jump to Main Content
Regioselective three-component synthesis of 1,2-diarylindoles from cyclohexanones, α-hydroxyketones and anilines under transition-metal-free conditions
- Li, Cheng, Xie, Yanjun, Xiao, Fuhong, Huang, Huawen, Deng, Guo-Jun
- Chemical communications 2019 v.55 no.28 pp. 4079-4082
- aromatization, chemical bonding, cyclohexanones, dehydrogenation, regioselectivity, synthesis
- A facile method for the one-pot synthesis of 1,2-diarylindoles under transition-metal-free conditions is described. Cyclohexanones were used as the aryl sources via the dehydrogenative aromatization process. One C–C and two C–N bonds were selectively formed via a domino reaction. This protocol provides a convenient approach for the construction of valuable bioactive 1,2-diarylindoles from readily available cyclohexanones, α-hydroxyketones and anilines.