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Regioselective three-component synthesis of 1,2-diarylindoles from cyclohexanones, α-hydroxyketones and anilines under transition-metal-free conditions

Author:
Li, Cheng, Xie, Yanjun, Xiao, Fuhong, Huang, Huawen, Deng, Guo-Jun
Source:
Chemical communications 2019 v.55 no.28 pp. 4079-4082
ISSN:
1364-548X
Subject:
aromatization, chemical bonding, cyclohexanones, dehydrogenation, regioselectivity, synthesis
Abstract:
A facile method for the one-pot synthesis of 1,2-diarylindoles under transition-metal-free conditions is described. Cyclohexanones were used as the aryl sources via the dehydrogenative aromatization process. One C–C and two C–N bonds were selectively formed via a domino reaction. This protocol provides a convenient approach for the construction of valuable bioactive 1,2-diarylindoles from readily available cyclohexanones, α-hydroxyketones and anilines.
Agid:
6363372