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Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
- Zai, Yuxia, Feng, Yunchao, Zeng, Xianhai, Tang, Xing, Sun, Yong, Lin, Lu
- RSC advances 2019 v.9 no.18 pp. 10091-10093
- aminolevulinic acid, bromination, bromine, hydrolysis, industrialization
- Synthesis of 5-aminolevulinic acid (5-ALA) was presented with novel bromination of biobased methyl levulinate (ML), followed by ammoniation and hydrolysis. Copper bromide (CuBr₂) was employed as the bromination reagent with higher selectivity and activity instead of the conventional liquid bromine (Br₂). 5-ALA was obtained in a high yield (64%) and purity (>95%) by optimum design, which is of great potential in industrialization.