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Tandem Wittig – Reductive annulation decarboxylation approach for the synthesis of indole and 2-substituted indoles

Author:
Volvoikar, Prajesh S., Tilve, S.G.
Source:
Tetrahedron letters 2018 v.59 no.19 pp. 1851-1854
ISSN:
0040-4039
Subject:
active ingredients, chemical structure, decarboxylation, indoles
Abstract:
A simple tandem Wittig reaction-reductive decarboxylation route is established for the synthesis of indoles from commercially available o-nitrobenzaldehydes and a stable phosphorane. The method allows access to indoles in a very fast manner without involving any metal or expensive reagents or inert atmosphere. Also 2-substituted indoles are obtained which forms an important core of many biological active compounds.
Agid:
6366030