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Estimates of dietary exposure of Spanish population to packaging contaminants from cereal based foods contained in plastic materials

García Ibarra, Verónica, Sendón, Raquel, Bustos, Juana, Paseiro Losada, Perfecto, Rodríguez Bernaldo de Quirós, Ana
Food and chemical toxicology 2019 v.128 pp. 180-192
citrates, dietary exposure, diethyl phthalate, exposure assessment, food consumption, food packaging, foods, gas chromatography-mass spectrometry, humans, liquid chromatography, packaging materials, screening, tandem mass spectrometry, toxicology
Food packaging may be a potential source of contamination, through the migration of chemicals from the packaging into the food, thus food consumption is an important route of human exposure to packaging contaminants.In the present study an approach to estimate the exposure to different chemicals transferred from food packaging was designed. As a first step a GC-MS screening was conducted to identify potential contaminants in the materials. Secondly, different chemicals previously identified in the packaging materials were selected for exposure assessment. The proposed methodology was applied to cereal based foods packed with plastic packaging. A variety of chemicals including e.g. acetyl tributyl citrate (ATBC), bis (2-ethylhexyl) adipate (DEHA) and diethyl phthalate (DEP) among others were identified and analyzed in the foodstuffs. For this purpose a LC-MS/MS method was developed.The selected foodstuffs were pooled into three groups according to the population age (12–35 months, 3–9 years and 10–17 years) and based on the Spanish consumption data (Enalia).In general, ATBC mean exposure was higher than that of phthalates and DEHA for the three groups considered, with mean dietary exposure values ranging from 1.01 μg/kg bw/day (pool 12–35 months) to 2.01 μg/kg bw/day (pool 3–9 years).