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Highly Thiolated Dendritic Mesoporous Silica Nanoparticles with High-Content Gold as Nanozymes: The Nano-Gold Size Matters
- Kalantari, Mohammad, Ghosh, Trisha, Liu, Yang, Zhang, Jun, Zou, Jin, Lei, Chang, Yu, Chengzhong
- ACS applied materials & interfaces 2019 v.11 no.14 pp. 13264-13272
- nanogold, nanoparticles, porous media, silica, thiols
- Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g–¹) are synthesized and used to load gold nanoparticles with tunable sizes (1.2–2.7 nm) and high content (34.0 wt %). It is demonstrated that the size of gold nanoparticles has a significant impact on their peroxidase-mimicking activity. At an optimized size of 1.9 nm, T-DMSNs@Au exhibits the highest activity. Our contribution provides new insights into the rational design of nanozymes for future applications.