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⁶⁸Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis

Author:
Wahsner, Jessica, Désogère, Pauline, Abston, Eric, Graham-O’Regan, Katherine A., Wang, Junfeng, Rotile, Nicholas J., Schirmer, Markus D., Santos Ferreira, Diêgo Dos, Sui, Jingyi, Fuchs, Bryan C., Lanuti, Michael, Caravan, Peter
Source:
Journal of the American Chemical Society 2019 v.141 no.14 pp. 5593-5596
ISSN:
1520-5126
Subject:
collagen, fibrosis, image analysis, lungs, lysine, oxidation, positron-emission tomography
Abstract:
Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, ⁶⁸Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of ⁶⁸Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated (R² = 0.98) with the concentration of lung allysine.
Agid:
6368023