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Co-assembled supramolecular hydrogels of doxorubicin and indomethacin-derived peptide conjugates for synergistic inhibition of cancer cell growth

Author:
Mei, Leixia, He, Suyun, Liu, Ziqi, Xu, Keming, Zhong, Wenying
Source:
Chemical communications 2019 v.55 no.30 pp. 4411-4414
ISSN:
1364-548X
Subject:
cell growth, chemical reactions, doxorubicin, hydrogels, indomethacin, moieties, nanomaterials, neoplasm cells, neoplasms, peptides
Abstract:
Conjugation of indomethacin with a self-assembling peptide moiety affords co-assembled supramolecular nanostructures of doxorubicin and peptide derivatives for tunable release of two drugs and synergistic effects against cancer cells, which illustrates a simple and effective approach to utilize co-assembled nanostructures for co-delivery of self-complementary drug pairs.
Agid:
6368122