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Magnesium-mediated arylation of amines via C–F bond activation of fluoroarenes

Author:
Bole, Leonie J., Davin, Laia, Kennedy, Alan R., McLellan, Ross, Hevia, Eva
Source:
Chemical communications 2019 v.55 no.30 pp. 4339-4342
ISSN:
1364-548X
Subject:
Lewis bases, ambient temperature, amides, amines, arylation, chemical bonding, ligands, magnesium, microwave treatment
Abstract:
A series of new Mg(ii) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.
Agid:
6368151