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Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from Klebsiella pneumonia ATCC 13883
- You, Hee Sang, Ok, Yeon Jeong, Lee, Song Hee, Kang, Sang Sun, Hyun, Sung Hee
- Indian journal of microbiology 2019 v.59 no.2 pp. 241-245
- Klebsiella pneumoniae, chemokine CCL3, epithelial cells, epithelium, gene expression, gene expression regulation, genes, immune response, interleukin-8, mast cells, pathogenicity
- We investigated alterations in the expression of immune-related genes in epithelial cells and mast cells treated with outer membrane vesicles (OMVs) derived from Klebsiella pneumoniae (KpOMVs). Previous studies have shown that OMVs contain substances that enable their delivery to host cells and induce an immune response. Our results indicate an increase in expression of genes such as IL-8, IL-1b, MIP-1α, HMOX1, HSPA1A, and IL-24 in epithelial cells and mast cells treated with KpOMVs. The pathogenicity of KpOMVs was confirmed by measuring the changes in the expression of these immune-related genes.