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The intestinal absorption properties of flavonoids in Hippophaƫ rhamnoides extracts by an in situ single-pass intestinal perfusion model

Author:
Xin, Lei, Liu, Xiao-Hui, Yang, Jun, Shen, Hong-Yi, Ji, Guang, Shi, Xiu-Feng, Xie, Yan
Source:
Journal of Asian natural products research 2019 v.21 no.1 pp. 62-75
ISSN:
1477-2213
Subject:
absorption, active transport, intestinal absorption, intestinal microorganisms, intestines, isorhamnetin, kaempferol, models, proteins, quercetin
Abstract:
The purpose of this study was to investigate the absorption properties of isorhamnetin (IS), quercetin (QU), and kaempferol (KA) in total flavones of Hippophaƫ rhamnoides L. (TFH) by an in situ single-pass intestinal perfusion model. The results indicated that IS, QU, and KA in TFH were absorbed site-dependently, and both enterohepatic circulation and intestinal flora could participate in their absorption processes. The absorption mechanisms of IS, QU, and KA in TFH were involved in both passive diffusion and active transport, and the mediation of efflux transporter multidrug resistance-associated proteins (MRPs) should not be neglected.
Agid:
6369711