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A new para-quinone-type flavan from the leaves of Ilex centrochinensis and its anti-inflammatory activities

Author:
Long, Hui, Yan, Qin-Fang, Hu, Ze-Hua, Zhang, Qiang, Chen, Yu, Li, Lu-Jun
Source:
Journal of Asian natural products research 2019 v.21 no.1 pp. 86-92
ISSN:
1477-2213
Subject:
Ilex, anti-inflammatory activity, chemical structure, cytotoxicity, flavonoids, leaves, quinones, spectral analysis
Abstract:
A new para-quinone-type flavan, (2S)-7-methoxy-3′,4′-dihydroxy-5,8-quinoflavan (1), together with three known compounds, were isolated from the leaves of Ilex centrochinensis. Their structures were elucidated by detailed spectroscopic analyses for new structure and in comparison with published data for known compounds. Moreover, the new compound was evaluated its cytotoxic and anti-inflammatory activities in vitro on LPS induced RAW 264.7 cells and the results showed that 1 has promising anti-inflammatory activities.
Agid:
6369717