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Two-Dimensional Atomically Thin Tin-Based Fluorescent Oxide Synthesized at Ambient Temperature and Its Biomedical Applications

Author:
Sharma, Nallin, Pandey, Sunil, Sharma, Amit Kumar, Wu, Hui-Fen
Source:
ACS sustainable chemistry & engineering 2019 v.7 no.8 pp. 7479-7485
ISSN:
2168-0485
Subject:
X-ray photoelectron spectroscopy, acetone, ambient temperature, biocompatibility, fluorescence, image analysis, nanoparticles, nanosheets, neoplasm cells, oxygen, sol-gel processing, sonication, tin, tin dioxide, viability
Abstract:
Synthesis of atomically thin tin oxide nanosheets using a nonhydrolytic sol–gel method at ambient temperature is reported in the present work. After 10 min of probe sonication and 7 days of incubation at ambient temperature, ultrathin tin oxide nanosheets (SnONS) from 2 nm to 5 μm were formed due to interaction between tin chloride and acetone. The most upsurging property of SnONS was the inherent yellow fluorescence (λₑₓ= 420 and λₑₘ₌ 540 nm) phenomenon rarely reported with respect to tin-based nanosheets. The relative quantum yield of SnONS was ∼16%. The origin of fluorescence in SnONS is speculated to originate from multiple transitions in oxygen states of Sn, as confirmed by X-ray photoelectron spectroscopy. For biological applications, SnONS was phase transferred from acetone to water without compromising the fluorescent properties of SnONS. Image cytometry (Nucleo-Counter NC-3000) and laser confocal microscopy were used for comprehending the cellular biocompatibility and internalization of nanoparticles inside the cells (biological imaging). With respect to control (100%), viability and vitality of the cancer cells were found to be 60.4% and 64%, respectively, after 12 h of interaction with SnONS.
Agid:
6372053