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DDQ-promoted C(sp3)H phosphorylation of cycloheptatriene
- Wen, Chunxiao, Yu, Guodian, Ou, Yingcong, Wang, Xiaofeng, Zhang, Kun, Chen, Qian
- Tetrahedron letters 2019 v.60 no.19 pp. 1345-1348
- ambient temperature, moieties, organic compounds, phosphorylation
- An efficient and convenient C(sp3)H phosphorylation has been achieved via the DDQ-promoted cross-dehydrogenative coupling between cycloheptatriene and P(O)H compounds at room temperature. This transformation provides a direct synthetic route to the construction of C(sp3)P bonds with good functional group compatibility, leading to the formation of cyclohepta-2,4,6-trien-1-ylphosphonates in up to 99% yield.