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Direct Synthesis of 2,3-Diaroyl Quinolines and Pyridazino[4,5-b]quinolines via an I₂-Promoted One-Pot Multicomponent Reaction
- Zhao, Peng, Wu, Xia, Zhou, You, Geng, Xiao, Wang, Can, Wu, Yan-dong, Wu, An-Xin
- Organic letters 2019 v.21 no.8 pp. 2708-2711
- amines, chemical structure, cycloaddition reactions, ketones, quinoline
- The first synthesis of 2,3-diaroyl quinolines via a formal [3 + 2 + 1] cycloaddition of enaminones, aryl methyl ketones, and aryl amines is disclosed. This reaction efficiently affords a 1,4-dicarbonyl scaffold, which is a useful building block for constructing complex fused heterocycles. Furthermore, the 1,4-dicarbonyl scaffold has been used directly to prepare pyridazino[4,5-b]quinoline skeletons in one-pot.