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Synthesis of 2,4,5-Trisubstituted Oxazoles via Pd-Catalyzed C–H Addition to Nitriles/Cyclization Sequences

Author:
Zhang, Di, Song, Hao, Cheng, Na, Liao, Wei-Wei
Source:
Organic letters 2019 v.21 no.8 pp. 2745-2749
ISSN:
1523-7052
Subject:
catalytic activity, chemical reactions, chemical structure, nitriles, oxazoles, palladium
Abstract:
A practical and flexible intermolecular protocol for the diverse synthesis of trisubstituted oxazole derivatives via a Pd-catalyzed direct C–H addition of electronic-rich heteroarenes to O-acyl cyanohydrins bearing an α-hydrogen/cyclization sequence is described. A wide range of trisubstituted oxazoles can be prepared from readily available starting materials in good to high yields with high efficiency under redox neutral reaction conditions.
Agid:
6375953