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Bacopa phospholipid complex retrieves aluminum maltolate complex–induced oxidative stress and apoptotic alterations in the brain regions of albino rat

Author:
Tirumanyam, Madhavi, Nadella, Rasajna, Kondammagari, Saritha, Borelli, Deva Prasad Raju, Nannepaga, John Sushma
Source:
Environmental science and pollution research international 2019 v.26 no.12 pp. 12071-12079
ISSN:
0944-1344
Subject:
Bacopa, aluminum, antioxidants, apoptosis, bioavailability, catalase, cerebellum, cerebral cortex, enzyme activity, glutathione peroxidase, hippocampus, immunohistochemistry, medulla oblongata, neurotoxicity, oxidative stress, phospholipids, rats, superoxide dismutase, therapeutics, thiobarbituric acid-reactive substances
Abstract:
Highly bioavailable plant phospholipid complex that can reverse aluminum maltolate (AlM)–induced toxicity is not yet reported. Hence, the present study was planned to investigate the impact of oxidative stress and apoptotic changes provoked by Al and ameliorative role of Bacopa phospholipid complex (BPC) in albino rats. The levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase activity (CAT), glutathione peroxidase (GPx), and thiobarbituric acid–reactive substance (TBA-RS) were measured and immunohistochemistry analysis of apoptotic markers, Bax and Bcl-2, was done from the four brain regions such as the hippocampus, cerebral cortex, cerebellum, and medulla oblongata. The levels of antioxidant enzymes and apoptotic markers that were decreased on AlM induction showed a significant increase in their levels, almost as observed in the control, when treated with BPC and Bm. Our results indicate that both BPC and Bm showed a therapeutic effect against AlM toxicity; however, it was found that the therapeutic potential of BPC was more pronounced than Bm against AlM-induced neurotoxicity.
Agid:
6377757