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Health‐promoting effects of dietary polysaccharide extracted from Dendrobium aphyllum on mice colon, including microbiota and immune modulation

Liu, Huifan, Wu, Hui, Wang, Qin
International journal of food science & technology 2019 v.54 no.5 pp. 1684-1696
CD4-positive T-lymphocytes, Dendrobium, Erysipelotrichaceae, Ruminococcaceae, colon, gastrointestinal transit, health promotion, homeostasis, immunomodulation, interleukin-6, mice, microorganisms, oral administration, pH, polysaccharides, short chain fatty acids
The health‐promoting effects of a polysaccharide (DAP) purified from Dendrobium aphyllum, on mice colon were investigated. The results indicated that consumption of DAP facilitated the differentiation degree of CD4⁺ T cells to Th₁, Th₁₇ and Treg cells; and depressed the differentiation degree to Th₂ cells, since DAP up‐regulated IL‐6 expression (from 1.08 ± 0.24 to 3.40 ± 0.36). Besides, oral administration of DAP reduced the gastrointestinal transit time from 255 ± 1.21 to 164 ± 0.46 min, decreased the pH from 6.70 ± 0.27 to 5.54 ± 0.31, improved faecal water‐binding capability from 59.4% ± 0.35 to 63.5% ± 0.22. Additionally, the increase in four health‐promoting short chain fatty acids were observed, which might result from the enrichment of the relative abundance of health‐promoting microbiota genera, including Porphyromonadaceae and Ruminococcaceae. The DAP‐induced up‐regulation of the genus Erysipelotrichaceae might be related to the homeostasis in both Th₁/Th₂ and Treg/Th₁₇.