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Isolation of two distinct prion strains from a scrapie-affected sheep

Author:
Masujin, Kentaro, Shu, Yujing, Okada, Hiroyuki, Matsuura, Yuichi, Iwamaru, Yoshifumi, Imamura, Morikazu, Mohri, Shirou, Yokoyama, Takashi
Source:
Archives of virology 2009 v.154 no.12 pp. 1929-1932
ISSN:
0304-8608
Subject:
brain, mice, obesity, phenotype, primary transmission, scrapie, sheep, weight loss, Japan
Abstract:
We performed a transmission study using mice to clarify the characteristics of the most recent case of scrapie in Japan. The mice that were inoculated with the brain homogenate from a scrapie-affected sheep developed progressive neurological disease, and one of the scrapie-affected mice showed unique clinical signs during primary transmission. This mouse developed obesity, polydipsia, and polyuria. In contrast, the other affected mice exhibited weight loss and hypokinesia. In subsequent passages, the mice showed distinct characteristic scrapie phenotypes. This finding may prove that different prion strains coexist in a naturally affected sheep with scrapie.
Agid:
637827