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Cryspovirus: a new genus of protozoan viruses in the family Partitiviridae
- Nibert, Max L., Woods, Keith M., Upton, Steve J., Ghabrial, Said A.
- Archives of virology 2009 v.154 no.12 pp. 1959-1965
- Cryptosporidium parvum, Partitiviridae, capsid, double-stranded RNA, genome, mycoviruses, new genus, new species, parasites, transcription (genetics), virion
- The family Partitiviridae includes plant and fungal viruses with bisegmented dsRNA genomes and isometric virions in which the two genome segments are packaged separately and used as templates for semiconservative transcription by the viral polymerase. A new genus, Cryspovirus, has been approved for this family. Its name is based on that of the host genus, Cryptosporidium, which encompasses several species of apicomplexan parasites that infect a wide range of mammals, birds, and reptiles, and are a major cause of human diarrheal illness worldwide. The type species of the new genus is Cryptosporidium parvum virus 1. Distinguishing characteristics include infection of a protozoan host, a smaller capsid protein than found in other members of the family Partitiviridae, and sequence-based phylogenetic divergence.