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Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin
- Lin, Jian-Tao, Ye, Qing-Bang, Yang, Qing-Jin, Wang, Guan-Hai
- Colloids and surfaces 2019 v.180 pp. 93-101
- apoptosis, blood circulation, coatings, crosslinking, curcumin, disulfide bonds, doxorubicin, drug therapy, human cell lines, hydrogels, nanocarriers, neoplasm cells, neoplasms, pH, synergism
- Hierarchical responsive nanocarriers have received much attention for targeted delivery of chemotherapeutics. In this study, we designed pH and redox dual-stage responsive nanocarriers in the different delivery stages for co-delivery phosphorylated curcumin (p-Cur) with doxorubicin (Dox). The MSNs nanocarriers were functionalized via specific cleavable PEGylation and hydrogel coating crosslinked by disulfide bonds: MSNs as core load Dox; p-Cur encapsulated in hydrogel coating. In blood circulation, PEGylation endow the nanocarriers with long time during blood circulation; while in tumor tissue, PEG shells could be cleaved due to the pH-sensitive bond and expose the cationic hydrogel coating to improve cell uptake; while inside tumor cells, hydrogel coating could be cleaved due to the GSH and release the drugs. The results showed that the dual-responsive shells endowed the nanocarriers with tumor extracellular pH-triggered cell uptake and specific cancer cell target release. The synergistic effects of the p-Cur and Dox enhanced cellular apoptosis in Hela cells.