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Antibacterial activities of a series of novel 5-O-(4′, 6′-O-dimodified)-mycaminose 14-membered ketolides

Author:
Zhao, Zhe-Hui, Wang, A-Peng, Zhang, Xiao-Xi, Yang, Shuang, Luo, Zhi-Gang, Lei, Ping-Sheng
Source:
Journal of Asian natural products research 2019 v.21 no.5 pp. 456-461
ISSN:
1477-2213
Subject:
antibacterial properties, ketolides, pathogens
Abstract:
A series of novel 5-O-(4′,6′-O-dimodified)-mycaminose 14-membered ketolides were assessed for their in vitro antibacterial activities against a panel of sensitive and resistant pathogens. Compound 1 and compound 2, two ester analogs, showed the best antibacterial activities against several macrolide-sensitive and macrolide-resistant strains. These results indicated that introducing ester to 6-OH and a small volume ether substituent to the 4-OH of mycaminose could improve the antibacterial activities of ketolides.
Agid:
6382172