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Mimengosides J and K: two new neuroprotective triterpenoids from the fruits of Buddleja lindleyana

Author:
Zhang, Wei, Li, Zheng, Xu, Feng-Qing, Ren, Ya-Shuo, Xu, Shuang-Wang, Wang, Tong-Sheng, Liu, Jin-Song, Wu, De-Ling
Source:
Journal of Asian natural products research 2019 v.21 no.5 pp. 426-434
ISSN:
1477-2213
Subject:
Buddleja lindleyana, fruits, neurodegenerative diseases, protective effect, spectral analysis, triterpenoids
Abstract:
Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP⁺) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease.
Agid:
6382175