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Quassinoids from Picrasma quassioides and Their Neuroprotective Effects
- Zhao, Wen-Yu, Song, Xiao-Yu, Zhao, Lu, Zou, Chun-Xin, Zhou, Wei-Yu, Lin, Bin, Yao, Guo-Dong, Huang, Xiao-Xiao, Song, Shao-Jiang
- Journal of natural products 2019 v.82 no.4 pp. 714-723
- Picrasma quassioides, apoptosis, caspase-3, circular dichroism spectroscopy, neuroprotective effect, quantum mechanics, spectral analysis, stems, triterpenoids
- Quassinoids are a class of highly oxygenated degraded triterpenoids exclusively discovered from plants of the Simaroubaceae family. In this study, eight new (1–8) and 15 known quassinoids (9–23) were isolated from an extract of the stems of Picrasma quassioides. The structures were elucidated by spectroscopic analysis and electronic circular dichroism spectra combined with quantum chemical calculations. Compounds 4 and 5 represent the first examples of 18-nor-quassinoids from P. quassioides. All isolates were screened for their neuroprotective activities toward H₂O₂-induced cell damage in SH-SY5Y cells. Further study revealed that the potential protective activities of these compounds appeared to occur via the suppression of cell apoptosis and downregulation of caspase-3 activation.