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Evaluation of a high-resolution micro-sized magic angle spinning (HRμMAS) probe for NMR-based metabolomic studies of nanoliter samples

Author:
Duong, Nghia Tuan, Endo, Yuki, Nemoto, Takahiro, Kato, Hiroshi, Bouzier-Sore, Anne-Karine, Nishiyama, Yusuke, Wong, Alan
Source:
Analytical methods 2016 v.8 no.37 pp. 6815-6820
ISSN:
1759-9679
Subject:
metabolomics, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
This study evaluates the performances of a recently introduced 1 mm HRμMAS NMR probe for metabolic profiling of nanoliter samples. It examines essential NMR criteria such as spectral data qualities and repeatability, and experimental practicality. The report also discusses the difficulties related to the sample preparation in HRμMAS experiments and considers possible solutions and improvements.
Agid:
6384098