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Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold

Author:
Yokoi, Taiki, Ueda, Tomomi, Tanimoto, Hiroki, Morimoto, Tsumoru, Kakiuchi, Kiyomi
Source:
Chemical communications 2019 v.55 no.13 pp. 1891-1894
ISSN:
1364-548X
Subject:
chemical reactions, diazo compounds, nitrogen, oximes
Abstract:
This paper reports the selective conversion of alkyl azido groups at the carbonyl α-position into oximes through β-elimination of dinitrogen, followed by transoximation. With this method and diazo conversion, a triazido molecule was transformed into a triple click conjugation scaffold allowing one-pot four-component coupling.
Agid:
6384914