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Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold
- Yokoi, Taiki, Ueda, Tomomi, Tanimoto, Hiroki, Morimoto, Tsumoru, Kakiuchi, Kiyomi
- Chemical communications 2019 v.55 no.13 pp. 1891-1894
- chemical reactions, diazo compounds, nitrogen, oximes
- This paper reports the selective conversion of alkyl azido groups at the carbonyl α-position into oximes through β-elimination of dinitrogen, followed by transoximation. With this method and diazo conversion, a triazido molecule was transformed into a triple click conjugation scaffold allowing one-pot four-component coupling.