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Double-headed nanosystems for oral drug delivery

Author:
KaurThese authors contributed equally to this article., G., Arora, M., Ganugula, R., Kumar, M. N. V. Ravi
Source:
Chemical communications 2019 v.55 no.33 pp. 4761-4764
ISSN:
1364-548X
Subject:
bioavailability, chemical reactions, curcumin, drugs, encapsulation, ligands, nanotechnology, polyesters
Abstract:
We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces. The in vivo results suggest that the bioavailability of encapsulated curcumin is proportional to the ligand density rendered by double-headed nanosystems.
Agid:
6384925