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Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors

Author:
Gunasekara, Roshan W., Zhao, Yan
Source:
Chemical communications 2019 v.55 no.33 pp. 4773-4776
ISSN:
1364-548X
Subject:
binding capacity, chemical compounds, glycosphingolipids, hydroxylation, nanoparticles, receptors
Abstract:
Nanoparticle receptors were synthesized through micellar imprinting to bind glycosphingolipids with 20–140 μM binding affinities, meanwhile distinguishing glycan composition, the number of acyl chains, and hydroxylation of acyl chains in the lipids. The strong binding enabled the receptors to protect their target glycolipids dispersed in lipid membranes from enzymatic degradation.
Agid:
6385204