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Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Author:
Agarwal, Vipul, ToshniwalThese authors contributed equally., Priyanka, Smith, Natalie E., Smith, Nicole M., Li, Binbin, Clemons, Tristan D., Byrne, Lindsay T., Kakulas, Foteini, Wood, Fiona M., Fear, Mark, Corry, Ben, Swaminathan Iyer, K.
Source:
Chemical communications 2015 v.52 no.2 pp. 327-330
ISSN:
1364-548X
Subject:
chemical compounds, chemical reactions, collagen, mannose, transforming growth factor beta 1
Abstract:
Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFβ₁ mediated upregulation of profibrotic marker, collagen I.
Agid:
6385995