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Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines

Author:
Li, Yajun, Chao, Allen, Fleming, Fraser F.
Source:
Chemical communications 2016 v.52 no.10 pp. 2111-2113
ISSN:
1364-548X
Subject:
alkylation, imidazoles, organochlorine compounds, pyridines, quinolones
Abstract:
Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a chloroquinoline provide imidazoles and an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis.
Agid:
6386328