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Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

Author:
Tabe, Hiroyasu, Shimoi, Takuya, Boudes, Marion, Abe, Satoshi, Coulibaly, Fasséli, Kitagawa, Susumu, Mori, Hajime, Ueno, Takafumi
Source:
Chemical communications 2016 v.52 no.24 pp. 4545-4548
ISSN:
1364-548X
Subject:
chemical reactions, crystals, cytotoxicity, irradiation, light, manganese, recombinant fusion proteins, transcription factor NF-kappa B
Abstract:
Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.
Agid:
6386802