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A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Author:
ZhangBoth authors contributed equally., Liyun, Er, Jun Cheng, Jiang, Hao, Li, Xin, Luo, Zhaofeng, Ramezani, Thomas, Feng, Yi, Tang, Mui Kee, Chang, Young-Tae, Vendrell, Marc
Source:
Chemical communications 2016 v.52 no.58 pp. 9093-9096
ISSN:
1364-548X
Subject:
chemical reactions, image analysis, superoxide dismutase
Abstract:
Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.
Agid:
6387080