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Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Author:
Sun, Yuan, Kaplan, Jonah A., Shieh, Aileen, Sun, Hui-Lung, Croce, Carlo M., Grinstaff, Mark W., Parquette, Jon R.
Source:
Chemical communications 2016 v.52 no.30 pp. 5254-5257
ISSN:
1364-548X
Subject:
chemical reactions, cytotoxicity, fluorouracil, human cell lines, humans, hydrogels, nanofibers, nanotubes, neoplasm cells
Abstract:
The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.
Agid:
6387389