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A new diarylheptanoid and a new diarylheptanoid glycoside isolated from the roots of Juglans mandshurica and their anti-inflammatory activities

Author:
Diao, Shengbao, Jin, Mei, Sun, Jinfeng, Zhou, Yi, Ye, Chao, Jin, Yong, Zhou, Wei, Li, Gao
Source:
Natural product research 2019 v.33 no.5 pp. 701-707
ISSN:
1478-6427
Subject:
Juglans mandshurica, anti-inflammatory activity, glycosides, heptane, interleukin-6, nitric oxide, nuclear magnetic resonance spectroscopy, roots, tumor necrosis factor-alpha
Abstract:
A new diarylheptanoid, (2S,3S,5S)-2,3,5-trihydroxy-1,7-bis(4-hydroxy- 3-methoxyphenyl)heptane (1), and a new diarylheptanoid glycoside, (2S,3S,5S)-2,3-dihydroxy-5-O-β-d-xylopyranosyl-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)heptane (2), together with three known compounds, rhoiptelol C (3), rhoiptelol B (4) and 3′,4″-epoxy-2-O-β-d-glucopyanosyl-1-(4-hydroxyphenyl)- 7-(3-methoxyphenyl)heptan-3-one (5) were isolated from the roots of Juglans mandshurica (Juglandaceae). The structures of compounds 1 and 2 were identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. Compounds 1–5 were assayed for their inhibitory effects on the production of NO, TNF-α and IL-6 in LPS-stimulated RAW264.7 cells.
Agid:
6388612