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Determination of the Inhibitory Activity of Ferula sinkiangensis Polysaccharides for Protein Tyrosine Phosphatase 1B

Author:
Wulamu, S., Yimamu, H., Abuduwaili, A., Mutailifu, P., Maksimov, V. V., Gao, Y. H., Yili, A., Aisa, H. A.
Source:
Chemistry of natural compounds 2019 v.55 no.2 pp. 235-238
ISSN:
0009-3130
Subject:
Ferula sinkiangensis, arabinose, chemistry, fructose, galactose, galacturonic acid, polysaccharides, protein-tyrosine-phosphatase, rhamnose, roots, xylose
Abstract:
Polysaccharide fractions were sequentially extracted in 28.86 wt% yield from roots of Ferula sinkiangensis K. M. Shen. The polysaccharide fractions from F. sinkiangensis were identified as heteropolysaccharides and contained primarily the monosaccharides glucuronic and galacturonic acids, rhamnose, xylose, arabinose, galactose, and fructose. The isolated polysaccharide fractions at low concentrations exhibited in vitro inhibitory activity for protein-tyrosine phosphatase 1B. The degree of inhibition correlated with the galactose content in the polysaccharide fractions.
Agid:
6388659