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Triterpenoids from Phytolacca acinosa

Author:
Ma, Xiao-Pan, Lou, Hua-Yong, Zhang, Wen-Fang, Song, Jun-Rong, Li, Yan, Pan, Wei-Dong
Source:
Chemistry of natural compounds 2019 v.55 no.2 pp. 292-295
ISSN:
0009-3130
Subject:
Escherichia coli, Phytolacca acinosa, Staphylococcus aureus, antimicrobial properties, chemical bonding, cytotoxicity, human cell lines, humans, macrophages, neoplasm cells, nuclear magnetic resonance spectroscopy, roots, triterpenoids, tumor necrosis factor-alpha
Abstract:
A new triterpene (1), named jaligonic acid B, together with three known triterpenoids, jaligonic acid (2), esculentoside H (3), and esculentoside B (4), was isolated from the roots of Phytolacca acinosa Roxb. The structure of compound 1 was determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) analyses. All these compounds were evaluated for their cytotoxicity against three human cancer cell lines (BEL-7402, HL-60, HepG2.2.1.5). Compound 4 showed moderate cytotoxic activity. The effects of these compounds on the release of TNF-α from macrophage RAW264.7 cells were also studied. They were also screened for antimicrobial activity against Staphylococcus aureus and Escherichia coli. A triterpene containing a conjugated double bond is reported for the first time in the Phytolaccaceae family.
Agid:
6388674