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Plasmonic nanohalo optical probes for highly sensitive imaging of survivin mRNA in living cells
- Qian, Guang-Sheng, Kang, Bin, Zhang, Zhuo-Lei, Li, Xiang-Ling, Zhao, Wei, Xu, Jing-Juan, Chen, Hong-Yuan
- Chemical communications 2016 v.52 no.74 pp. 11052-11055
- biomarkers, biotin, chemical compounds, chemical reactions, image analysis, messenger RNA, nanogold, neoplasms, pro-apoptotic proteins, streptavidin
- A strategy is designed for sensitive detection of tumor biomarker survivin mRNA based on resonance Rayleigh scattering of a single AuNP nanohalo probe that couples large gold nanoparticles (L-AuNPs, 52 nm) with small AuNPs (S-AuNPs, 18 nm) through the affinity interaction between streptavidin and biotin. This core–satellite plasmon ruler is further applied to imaging survivin mRNA in living cells.