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Acid-triggered release of doxorubicin from a hydrazone-linked Gd³⁺-texaphyrin conjugate

Author:
LeeM. H. L. and E. J. K. contributed equally to this study., Min Hee, Kim, Eun-Joong, Lee, Hyunseung, Park, Sun Young, Hong, Kwan Soo, Kim, Jong Seung, Sessler, Jonathan L.
Source:
Chemical communications 2016 v.52 no.69 pp. 10551-10554
ISSN:
1364-548X
Subject:
chemical reactions, doxorubicin, fluorescence, image analysis, pH
Abstract:
The hydrazone-based Gd³⁺-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off–On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.
Agid:
6389548