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Enantioselective synthesis of β-substituted chiral allylic amines via Rh-catalyzed asymmetric hydrogenation

Author:
WangThese authors contributed equally to this work., Qingli, Gao, Wenchao, Lv, Hui, Zhang, Xumu
Source:
Chemical communications 2016 v.52 no.79 pp. 11850-11853
ISSN:
1364-548X
Subject:
amines, drugs, enantioselective synthesis, enantioselectivity, hydrogenation
Abstract:
An asymmetric mono-hydrogenation of 2-acetamido-1,3-dienes catalyzed by a Rh–DuanPhos complex has been developed. This approach provides easy access to chiral allylic amines with excellent enantioselectivities and high regioselectivities. The products are valuable chiral building blocks for pharmaceuticals.
Agid:
6389653